Keim K L, Sigg E B
Pharmacol Biochem Behav. 1977 Jan;6(1):79-85. doi: 10.1016/0091-3057(77)90162-9.
In nonstressed rats, subcutaneous administration of haloperidol (HAL) and large doses of diazepam (DZ) increased plasma corticosterone (CS). Hypothalamic norepinephrine (NE) was lowered significantly by desmethylimipramine (DMI), HAL and, to a lesser extent, by DZ and phenobarbital (PHB). In rats pretreated with either DZ, DMI, HAL or PHB the restraint-induced rise of CS was diminished, DZ being most potent. CPZ had a variable effect, slightly increasing or decreasing the CS response. Pretreatment (16 hr) with pargyline (PA) did not affect the CS rise to stress. The reduction of hypothalamic NE evoked by restraint was attenuated by DZ, and to a lesser extent, by PHB and HAL. Restraint of PA-treated rats did not lower the PA-elevated hypothalamic NE. The stress-induced increase in hypothalamic dopamine was prevented by CPZ and, partially, by PHB. It is emphasized that the net plasma CS and brain catecholamine changes in response to stress are dependent on the drug-induced neuroendocrine feedback state prevalent immediately before commencement of the stress procedure.
在未受应激的大鼠中，皮下注射氟哌啶醇（HAL）和大剂量地西泮（DZ）可使血浆皮质酮（CS）升高。去甲丙咪嗪（DMI）、HAL可显著降低下丘脑去甲肾上腺素（NE）水平，地西泮和苯巴比妥（PHB）在较小程度上也可降低其水平。在预先用DZ、DMI、HAL或PHB处理的大鼠中，束缚诱导的CS升高有所减弱，其中DZ的作用最为显著。氯丙嗪（CPZ）的作用不一，可轻微增加或降低CS反应。用帕吉林（PA）预处理（16小时）不影响CS对应激的升高反应。束缚引起的下丘脑NE减少可被DZ减弱，PHB和HAL在较小程度上也有此作用。束缚PA处理的大鼠不会降低PA升高的下丘脑NE水平。应激诱导的下丘脑多巴胺增加可被CPZ阻止，PHB可部分阻止。需要强调的是，对应激反应时血浆CS和脑儿茶酚胺的净变化取决于应激程序开始前即刻普遍存在的药物诱导的神经内分泌反馈状态。
