Ahmed S P, Ahmad M, Ahmed S I, Najam R, Khurshid S J
Department of Pharmacology, Faculty of Pharmacy, University of Karachi.
J Pak Med Assoc. 1995 Jun;45(6):153-5.
Psychoactive drugs such as chlorpromazine, fluphenazine, haloperidol, propranolol and diazepam were evaluated for their ability to block stress induced changes in Wistar albino rats. The stress induced changes were monitored as the difference in plasma corticosterone (PCS) levels, before and after the administration of minimum effective doses of psychoactive drugs. Significant results were obtained with diazepam at the dose of 5-10 mg/kg and to a lesser extent with propranolol 20 mg/kg. Other drugs, at their minimum effective doses showed no significant change in plasma corticosterone levels.
对氯丙嗪、氟奋乃静、氟哌啶醇、普萘洛尔和地西泮等精神活性药物阻断应激诱导的Wistar白化大鼠变化的能力进行了评估。应激诱导的变化通过在给予最小有效剂量精神活性药物前后血浆皮质酮（PCS）水平的差异来监测。地西泮在5-10mg/kg剂量时获得了显著结果，普萘洛尔在20mg/kg剂量时也有一定程度的显著结果。其他药物在其最小有效剂量时，血浆皮质酮水平无显著变化。
