SHIV感染在猪尾猕猴和恒河猴中的致病性差异
Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques.
作者信息
Polacino Patricia, Larsen Kay, Galmin Lindsey, Suschak John, Kraft Zane, Stamatatos Leonidas, Anderson David, Barnett Susan W, Pal Ranajit, Bost Kristen, Bandivdekar A H, Miller Christopher J, Hu Shiu-Lok
机构信息
Washington National Primate Research Center, University of Washington, Seattle, WA, USA.
出版信息
J Med Primatol. 2008 Dec;37 Suppl 2(Suppl 2):13-23. doi: 10.1111/j.1600-0684.2008.00325.x.
BACKGROUND
Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases.
METHODS
We compared the in vivo infectivity and pathogenicity of a CCR5-tropic SHIV(SF162 P4) after intravenous, intravaginal or intrarectal inoculation in rhesus and pig-tailed macaques. Plasma viral load, peripheral blood CD4(+) T cell counts and clinical signs were monitored.
RESULTS
Both rhesus and pig-tailed macaques are similarly susceptible to SHIV(SF162 P4) infection by intravenous and mucosal routes. However, infection was significantly more robust in pig-tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig-tails vs. 2/24 rhesus (P < 0.013) and severe CD4(+) T-cell depletion in 2/21 pig-tails (vs. none in rhesus).
CONCLUSIONS
Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.
背景
在灵长类慢病毒感染后，食蟹猴和恒河猴表现出不同的致病性。然而，关于豚尾猴对慢病毒感染和疾病的比较易感性知之甚少。
方法
我们比较了CCR5嗜性的猴-人免疫缺陷病毒（SHIV，SF162 P4）经静脉、阴道或直肠接种后在恒河猴和豚尾猴体内的感染性和致病性。监测血浆病毒载量、外周血CD4(+) T细胞计数和临床症状。
结果
恒河猴和豚尾猴经静脉和黏膜途径对SHIV（SF162 P4）感染的易感性相似。然而，豚尾猴的感染明显比恒河猴更强烈，导致9/21只豚尾猴出现持续性病毒血症，而恒河猴为2/24只（P < 0.013），并且2/21只豚尾猴出现严重的CD4(+) T细胞耗竭（恒河猴无此情况）。
结论
结合早期观察结果，我们的发现强调了在比较不同猕猴物种的疫苗效力时考虑宿主遗传和免疫因素的重要性。
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