Department of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, United States.
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
Front Immunol. 2018 Mar 2;9:208. doi: 10.3389/fimmu.2018.00208. eCollection 2018.
Uterine microbiota have been reported under various conditions and populations; however, it is uncertain the level to which these bacteria are residents that maintain homeostasis, tourists that are readily eliminated or invaders that contribute to human disease. This review provides a historical timeline and summarizes the current status of this topic with the aim of promoting research priorities and discussion on this controversial topic. Discrepancies exist in current reports of uterine microbiota and are critically reviewed and examined. Established and putative routes of bacterial seeding of the human uterus and interactions with distal mucosal sites are discussed. Based upon the current literature, we highlight the need for additional robust clinical and translational studies in this area. In addition, we discuss the necessity for investigating host-microbiota interactions and the physiologic and functional impact of these microbiota on the local endometrial microenvironment as these mechanisms may influence poor reproductive, obstetric, and gynecologic health outcomes and sequelae.
已经有报道称在各种条件和人群中存在子宫微生物群；然而，这些细菌是维持体内平衡的常驻居民，还是容易被清除的访客，或者是导致人类疾病的侵略者，尚不确定。本综述提供了一个历史时间表，并总结了这一主题的现状，旨在促进对这一争议性主题的研究重点和讨论。目前关于子宫微生物群的报告存在差异，对此进行了批判性审查和检查。讨论了细菌定植人类子宫的既定和推测途径，以及与远端黏膜部位的相互作用。基于目前的文献，我们强调需要在这一领域进行更多的稳健的临床和转化研究。此外，我们还讨论了研究宿主-微生物群相互作用以及这些微生物群对局部子宫内膜微环境的生理和功能影响的必要性，因为这些机制可能会影响不良的生殖、产科和妇科健康结局和后遗症。
