前列环素（PGX）对人血小板腺苷酸环化酶的调节作用。

Modulation of human platelet adenylate cyclase by prostacyclin (PGX).

作者信息

Gorman R R, Bunting S, Miller O V

出版信息

Prostaglandins. 1977 Mar;13(3):377-88. doi: 10.1016/0090-6980(77)90018-1.

PMID:191876

Abstract

Prostacyclin (PGX) (57)-9-deoxy-6,9alpha-epoxy-delta5-PGF1alpha has been found to be a potent stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.

摘要

前列环素（PGX）（57）-9-脱氧-6,9α-环氧-δ5-前列腺素F1α已被发现是一种比前列腺素E1更有效的血小板中环磷酸腺苷（cAMP）积累刺激剂。前列环素对血小板cAMP积累的刺激可被前列腺素内过氧化物PGH2拮抗，而PGH2诱导的血小板聚集则被前列环素拮抗。提出了一种血小板内稳态模型，该模型表明血小板聚集受前列环素刺激腺苷酸环化酶的活性与PGH2降低cAMP的活性之间的平衡控制。