前列环素（PGX）对人血小板中环磷酸腺苷浓度的影响。
Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets.
作者信息
Tateson J E, Moncada S, Vane J R
出版信息
Prostaglandins. 1977 Mar;13(3):389-97. doi: 10.1016/0090-6980(77)90019-3.
PMID:191877
Abstract
Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times more active than PGE1 and more than 1000 times more active than its stable end product, 6-oxo-PGF1alpha. These results correlate well with the anti-aggregating activity of prostacyclin, compared with PGE1 and PGD2.
摘要
前列环素（PGX）可显著提高人血小板中环磷酸腺苷（cAMP）的浓度。前列环素的活性约为前列腺素D2（PGD2）的10倍、前列腺素E1（PGE1）的30倍，且比其稳定终产物6-氧代前列腺素F1α（6-oxo-PGF1α）的活性高1000倍以上。与PGE1和PGD2相比，这些结果与前列环素的抗聚集活性密切相关。
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