Miller O V, Johnson R A, Gorman R R
Prostaglandins. 1977 Apr;13(4):599-609. doi: 10.1016/0090-6980(77)90231-3.
The prostaglandin endoperoxide PGH2, HHT, HETE, thromboxane A2, and thromboxane B2, which are all products of arachidonic acid metabolism of human platelets, were tested for their ability to modulate platelet cyclic nucleotide levels. None of the compounds tested altered the basal level of cAMP or cGMP, and only PGH2 and thromboxane A2 inhibited PGE1-stimulated cAMP accumulation. Thromboxane A2 was found to be a more potent inhibitor of PGE1-stimulated cAMP accumulation and inducer of platelet aggregation than PGH2.
前列腺素内过氧化物PGH2、HHT、HETE、血栓素A2和血栓素B2均为人血小板花生四烯酸代谢产物，对它们调节血小板环核苷酸水平的能力进行了测试。所测试的化合物均未改变cAMP或cGMP的基础水平，只有PGH2和血栓素A2抑制了PGE1刺激的cAMP积累。发现血栓素A2比PGH2更有效地抑制PGE1刺激的cAMP积累并诱导血小板聚集。
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