为什么我们要给老鼠穿衣服。
Why we should put clothes on mice.
作者信息
Lodhi Irfan J, Semenkovich Clay F
机构信息
Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Cell Metab. 2009 Feb;9(2):111-2. doi: 10.1016/j.cmet.2009.01.004.
PMID:19187768
Abstract
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
摘要
线粒体解偶联蛋白1（UCP1）是适应性产热和能量消耗的关键调节因子。缺乏UCP1的小鼠对寒冷敏感，但令人惊讶的是，在室温下并不肥胖。在本期《细胞代谢》中，费尔德曼等人（2009年）通过简单地将这些小鼠维持在热中性状态，揭示了一种致肥胖表型。
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