长链非编码RNA：功能洞察
Long non-coding RNAs: insights into functions.
作者信息
Mercer Tim R, Dinger Marcel E, Mattick John S
机构信息
Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
出版信息
Nat Rev Genet. 2009 Mar;10(3):155-9. doi: 10.1038/nrg2521.
In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.
在哺乳动物和其他真核生物中，大部分基因组以发育调控的方式进行转录，产生大量的长链非编码RNA（ncRNA）。在此，我们综述长链ncRNA这一快速发展的领域，描述它们的保守性、在基因组中的组织方式及其在基因调控中的作用。我们还考虑了其医学意义，以及人们逐渐认识到的任何转录本，无论其编码潜力如何，都可作为一种RNA具有内在功能。
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