Kämmerer P W, Kreft A, Toyoshima T, Al-Nawas B, Klein M O
Department of Oral and Maxillofacial Surgery, Johannes Gutenberg-University, Augustusplatz 2, 55131, Mainz, Germany.
Oral Maxillofac Surg. 2009 Jun;13(2):99-103. doi: 10.1007/s10006-009-0150-z.
Polymorphous low-grade adenocarcinoma (PLGA) are frequent tumours of palatinal minor salivary glands. They appear clinically as solid mass located beneath intact surface epithelium, thus quite similar with benign neoplasm. PLGA displays a low tendency of aggressive behaviour. The correct aetiology of this disorder is still unknown.
In this contribution, a PLGA is reported which was located in a pleomorphic adenoma (PA). Out of an initially incisional biopsy, only the benign part of the lesion was diagnosed. Definitive histological examination of the whole tumour revealed a small malignant fraction of the specimen besides a major part of benign tissue formations (PA).
This case shows the uncertain confidence of incisional biopsy, the variably biologic behaviour of PA, providing hints for consideration of the PLGA aetiology and highlights both the necessity to remove whole PA-like lesions as well as to perform systematically histological examination of whole specimens.
多形性低度恶性腺癌（PLGA）是腭部小涎腺常见的肿瘤。临床上表现为位于完整表面上皮下方的实性肿块，因此与良性肿瘤非常相似。PLGA表现出较低的侵袭性行为倾向。这种疾病的确切病因仍然未知。
在本病例中，报告了一例位于多形性腺瘤（PA）内的PLGA。最初的切开活检仅诊断出病变的良性部分。对整个肿瘤进行的最终组织学检查显示，除了大部分良性组织形成（PA）外，标本中还有一小部分恶性成分。
本病例显示了切开活检的可信度不确定、PA的生物学行为多变，为考虑PLGA的病因提供了线索，并强调了切除整个PA样病变以及对整个标本进行系统组织学检查的必要性。
