Bumbu Bogdan Andrei, Moldovan Mădălina Anca, Moldovan Iuliu George, Precup Alexandru Iosif, Iurcov Raluca Ortensia
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Department of Oral-Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Med Pharm Rep. 2025 Jul;98(3):403-408. doi: 10.15386/mpr-2882. Epub 2025 Jul 30.
Polymorphous adenocarcinoma (PAC) is a type of salivary gland tumor that is rare and diverse in morphology. It is typically found in the minor salivary glands, with the palate being the most common location. However, this tumor is often misunderstood, underdiagnosed, and controversial in nomenclature. Its low-grade behavior may be unpredictable, making it challenging to manage.
In this paper, we detail a case of PAC that developed in the buccal mucosa, which is a less common anatomical location. We discuss the patient's clinical presentation, imaging findings, histological examination results, as well as the surgical treatment and follow-up outcomes. We also examine relevant literature related to the topic to provide a comprehensive understanding of this rare case.
Although complete surgical excision is the primary management for PAC, there is no gold standard treatment for it. It is crucial to follow up on patients with PAC in the long term, as recurrences, lymph nodes, and distant metastasis, even rare, may impair the prognosis in certain patients.
多形性腺癌（PAC）是一种唾液腺肿瘤，较为罕见，形态多样。它通常发生于小唾液腺，其中腭部是最常见的发病部位。然而，这种肿瘤常被误解、诊断不足且在命名上存在争议。其低级别行为可能难以预测，给治疗带来挑战。
在本文中，我们详细介绍了一例发生于颊黏膜的PAC病例，颊黏膜是一个不太常见的解剖位置。我们讨论了患者的临床表现、影像学检查结果、组织学检查结果，以及手术治疗和随访结果。我们还查阅了与该主题相关的文献，以全面了解这一罕见病例。
尽管完整手术切除是PAC的主要治疗方法，但目前尚无针对它的金标准治疗方案。对PAC患者进行长期随访至关重要，因为复发、淋巴结转移和远处转移，即使罕见，在某些患者中也可能影响预后。
