Jack Brian W, Chetty Veerappa K, Anthony David, Greenwald Jeffrey L, Sanchez Gail M, Johnson Anna E, Forsythe Shaula R, O'Donnell Julie K, Paasche-Orlow Michael K, Manasseh Christopher, Martin Stephen, Culpepper Larry
Department of Family Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA.
Ann Intern Med. 2009 Feb 3;150(3):178-87. doi: 10.7326/0003-4819-150-3-200902030-00007.
Emergency department visits and rehospitalization are common after hospital discharge.
To test the effects of an intervention designed to minimize hospital utilization after discharge.
Randomized trial using block randomization of 6 and 8. Randomly arranged index cards were placed in opaque envelopes labeled consecutively with study numbers, and participants were assigned a study group by revealing the index card.
General medical service at an urban, academic, safety-net hospital.
749 English-speaking hospitalized adults (mean age, 49.9 years).
A nurse discharge advocate worked with patients during their hospital stay to arrange follow-up appointments, confirm medication reconciliation, and conduct patient education with an individualized instruction booklet that was sent to their primary care provider. A clinical pharmacist called patients 2 to 4 days after discharge to reinforce the discharge plan and review medications. Participants and providers were not blinded to treatment assignment.
Primary outcomes were emergency department visits and hospitalizations within 30 days of discharge. Secondary outcomes were self-reported preparedness for discharge and frequency of primary care providers' follow-up within 30 days of discharge. Research staff doing follow-up were blinded to study group assignment.
Participants in the intervention group (n = 370) had a lower rate of hospital utilization than those receiving usual care (n = 368) (0.314 vs. 0.451 visit per person per month; incidence rate ratio, 0.695 [95% CI, 0.515 to 0.937]; P = 0.009). The intervention was most effective among participants with hospital utilization in the 6 months before index admission (P = 0.014). Adverse events were not assessed; these data were collected but are still being analyzed.
This was a single-center study in which not all potentially eligible patients could be enrolled, and outcome assessment sometimes relied on participant report.
A package of discharge services reduced hospital utilization within 30 days of discharge.
Agency for Healthcare Research and Quality and National Heart, Lung, and Blood Institute, National Institutes of Health.
出院后急诊就诊和再次住院的情况很常见。
测试一项旨在尽量减少出院后医院利用率的干预措施的效果。
采用6和8的区组随机化的随机试验。将随机排列的索引卡放入标有连续研究编号的不透明信封中,通过翻开索引卡为参与者分配研究组。
一家城市学术安全网医院的普通医疗服务部门。
749名讲英语的住院成年人(平均年龄49.9岁)。
一名护士出院倡导者在患者住院期间与其合作,安排随访预约、确认用药核对,并使用发送给其初级保健提供者的个性化指导手册进行患者教育。一名临床药剂师在出院后2至4天给患者打电话,强化出院计划并复查用药情况。参与者和提供者对治疗分配不设盲。
主要结局为出院后30天内的急诊就诊和住院情况。次要结局为自我报告的出院准备情况以及出院后30天内初级保健提供者的随访频率。进行随访的研究人员对研究组分配情况设盲。
干预组(n = 370)的医院利用率低于接受常规护理的组(n = 368)(每人每月0.314次就诊与0.451次就诊;发病率比,0.695 [95% CI,0.515至0.937];P = 0.009)。该干预措施在索引入院前6个月内有医院利用情况的参与者中最为有效(P = 0.014)。未评估不良事件;已收集这些数据但仍在分析中。
这是一项单中心研究,并非所有潜在符合条件的患者都能纳入,结局评估有时依赖参与者报告。
一套出院服务降低了出院后30天内的医院利用率。
医疗保健研究与质量局以及美国国立卫生研究院国家心肺血液研究所。