Chahine Lama M, Ghosh Debabrata
Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
J Child Neurol. 2009 Jul;24(7):861-4. doi: 10.1177/0883073808329528. Epub 2009 Feb 2.
Essential tremor is a long-recognized and common movement disorder, yet controversy still surrounds its pathophysiology. The olivo-cerebello-thalamo-cortical pathway has been implicated in the genesis of essential tremor, and the inferior olive has been considered the central oscillator driving the peripheral tremor. We present the case of a patient who developed essential tremor ipsilateral to cerebellar hemispherectomy and propose that the central oscillator in patients with essential tremor may not be the inferior olive in all cases, but rather the nucleus ventralis intermedius of the thalamus.
特发性震颤是一种早已被认识且常见的运动障碍，但围绕其病理生理学仍存在争议。橄榄-小脑-丘脑-皮质通路与特发性震颤的发生有关，下橄榄核被认为是驱动外周震颤的中枢振荡器。我们报告了一例小脑半球切除术后同侧发生特发性震颤的患者，并提出特发性震颤患者的中枢振荡器在所有情况下可能并非都是下橄榄核，而是丘脑腹中间核。
