Bertuccio P, Praud D, Chatenoud L, Lucenteforte E, Bosetti C, Pelucchi C, Rossi M, Negri E, La Vecchia C
Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa, 19, 20156 Milan, Italy.
Br J Cancer. 2009 Feb 10;100(3):558-61. doi: 10.1038/sj.bjc.6604894.
We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0-3.3) for GI and 2.5 (95% CI: 1.3-4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2-11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.
在1997年至2007年间于意大利北部开展的一项病例对照研究中，我们调查了胃癌风险与饮食血糖生成指数（GI）和血糖负荷（GL）之间的关系，GI和GL代表碳水化合物吸收以及由此产生的饮食胰岛素需求的间接指标。该研究纳入了230例新发的、经组织学确诊的胃癌患者以及547例频率匹配的对照，这些对照与病例来自同一些医院，患有急性非肿瘤性疾病。我们使用了条件逻辑回归模型，纳入了主要公认的胃癌风险因素和非碳水化合物能量摄入的相关项。GI最高五分位数与最低五分位数相比的比值比（OR）为1.9（95%置信区间：1.0 - 3.3），GL为2.5（95%置信区间：1.3 - 4.9）。与报告低GL且高水果/蔬菜摄入量的参与者相比，OR在高GL和低水果/蔬菜摄入量的分层中上升，对于报告低水果/蔬菜摄入量且高GL的参与者，OR达到5.0（95%置信区间：2.2 - 11.5）。我们的研究可能有助于解释在多项研究中观察到的淀粉类食物与胃癌风险之间的直接关系。
