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建立韩国婴幼儿严重下呼吸道感染监测网络。

Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children.

作者信息

Chun J-K, Lee J-H, Kim H-S, Cheong H-M, Kim K S, Kang C, Kim D S

机构信息

Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, South Korea.

出版信息

Eur J Clin Microbiol Infect Dis. 2009 Jul;28(7):841-4. doi: 10.1007/s10096-009-0701-0. Epub 2009 Feb 4.

Abstract

To reduce morbidity and mortality through integrated case management, a pilot study to detect respiratory viruses in patients with acute lower respiratory infections (ALRIs) was designed as part of a nationwide surveillance for this disease in Korea. The study population consisted of hospitalized patients under the age of 5 years with bronchiolitis, pneumonia, croup, or acute respiratory distress syndrome. A prospective 6-month study was performed. Two hundred and ninety-seven nasopharyngeal secretions were collected and multiplex reverse transcriptase polymerase chain reactions (RT-PCR)/polymerase chain reactions (PCR) were performed to detect respiratory viruses. If there were any positive RT-PCR/PCR results, viral cultures were proceeded for confirmation. Respiratory viruses were identified in 49.6% of 296 patients. The detection rates were as follows: respiratory syncytial virus (RSV) was the most commonly detected in 52.7% (87/165), human metapneumovirus (hMPV) in 15.8%, human corona virus (hCoV) in 5.5%, adenovirus in 9.7%, human bocavirus (hBoV) in 5.5%, parainfluenza virus (PIV) in 3.6%, rhinovirus (RV) in 4.2%, and the influenza virus in 3% of the patients with ALRIs. The consistent rate of positive results between RT-PCR and viral culture was 92% (105/114). Using our methods to detect viral causes seemed to be acceptable for the national surveillance of severe acute respiratory infections in infants and children.

摘要

为通过综合病例管理降低发病率和死亡率,作为韩国全国性该疾病监测的一部分,设计了一项针对急性下呼吸道感染(ALRIs)患者检测呼吸道病毒的试点研究。研究对象包括5岁以下因细支气管炎、肺炎、哮吼或急性呼吸窘迫综合征住院的患者。进行了一项为期6个月的前瞻性研究。收集了297份鼻咽分泌物,并进行多重逆转录聚合酶链反应(RT-PCR)/聚合酶链反应(PCR)以检测呼吸道病毒。如果RT-PCR/PCR结果呈阳性,则进行病毒培养以确认。在296例患者中,49.6%检测出呼吸道病毒。检测率如下:呼吸道合胞病毒(RSV)最常见,占52.7%(87/165),人偏肺病毒(hMPV)占15.8%,人冠状病毒(hCoV)占5.5%,腺病毒占9.7%,人博卡病毒(hBoV)占5.5%,副流感病毒(PIV)占3.6%,鼻病毒(RV)占4.2%,流感病毒占ALRIs患者的3%。RT-PCR与病毒培养结果的一致率为92%(105/114)。使用我们的方法检测病毒病因似乎可用于全国婴幼儿严重急性呼吸道感染监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6a/7088216/124b6dd18990/10096_2009_701_Fig1_HTML.jpg

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