弥漫性泛细支气管炎患者支气管肺泡灌洗分析研究——低剂量长期红霉素治疗结果
[A study of bronchoalveolar lavage analysis in patients with diffuse panbronchiolitis--the results of low dose and long term erythromycin treatment].
作者信息
Mukae H, Sakito O, Oda H, Senju R, Hiratani K, Kadota J, Fukushima K, Komori K, Kouno S, Hara K
机构信息
Second Department of Internal Medicine, Nagasaki University School of Medicine.
出版信息
Kansenshogaku Zasshi. 1991 Jun;65(6):692-7. doi: 10.11150/kansenshogakuzasshi1970.65.692.
Cellular analysis including lymphocyte surface markers in BALF in 17 patients with DPB (14 male; 36 female) was performed. The total number of cells increased remarkably, especially the percentage of neutrophils (72.9 +/- 14.1%). On the contrary the percentage of alveolar macrophage decreased (15.4 +/- 8.9%). The CD4/CD8 ratio in DPB was also significantly decreased to 0.73 +/- 0.38% when compared with normal healthy nonsmokers. Five patients with low dose and long term EM treatment were analyzed. Total cell counts as well as the neutrophil percentage (7.3 +/- 4.0%) decreased significantly. On the other hand the percentage of alveolar macrophage increased to 76.6 +/- 0.6%, which was almost similar to those obtained from normal healthy volunteers. Therefore it is concluded that both clinical and BALF findings improved concordantly after EM treatment.
对17例弥漫性泛细支气管炎患者（14例男性，3例女性）的支气管肺泡灌洗（BALF）进行了包括淋巴细胞表面标志物在内的细胞分析。细胞总数显著增加，尤其是中性粒细胞百分比（72.9±14.1%）。相反，肺泡巨噬细胞百分比下降（15.4±8.9%）。与正常健康非吸烟者相比，弥漫性泛细支气管炎患者的CD4/CD8比值也显著降低至0.73±0.38%。对5例接受低剂量长期红霉素治疗的患者进行了分析。细胞总数以及中性粒细胞百分比（7.3±4.0%）显著下降。另一方面，肺泡巨噬细胞百分比增加至76.6±0.6%，几乎与正常健康志愿者的水平相似。因此得出结论，红霉素治疗后临床和BALF检查结果均得到一致改善。
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