Nobile-Orazio Eduardo
Department of Neurological Sciences, Milan University, 2nd Neurology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy.
J Peripher Nerv Syst. 2008 Dec;13(4):261-3. doi: 10.1111/j.1529-8027.2008.00190.x.
Several articles on multifocal motor neuropathy (MMN) have appeared in 2007 and 2008, broadening the boundaries of this neuropathy and improving its diagnosis. A number of retrospective studies confirmed the prolonged efficacy of high-dose intravenous immunoglobulins (IVIg) in this neuropathy. The efficacy of other immune therapies was not however, confirmed in other studies in MMN including a randomized controlled trial on mycophenolate mofetil as adjunctive therapy to IVIg. These negative results and the lack of new other studies on the cause of MMN should lead to some reconsideration on its pathogenesis.
2007年和2008年发表了几篇关于多灶性运动神经病（MMN）的文章，拓宽了这种神经病的研究范围并改进了其诊断方法。多项回顾性研究证实了大剂量静脉注射免疫球蛋白（IVIg）对这种神经病具有持久疗效。然而，在MMN的其他研究中，包括一项关于霉酚酸酯作为IVIg辅助治疗的随机对照试验，并未证实其他免疫疗法的疗效。这些阴性结果以及缺乏关于MMN病因的其他新研究，应该促使人们对其发病机制进行一些重新思考。
