Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
J Am Chem Soc. 2009 Mar 4;131(8):2900-5. doi: 10.1021/ja807772w.
The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.
已合成了天然存在的且强效的组蛋白去乙酰化酶(HDAC)抑制剂 FK228 和 largazole 的肽类结构类似物(10 和 11),并与 FK228、largazole 和 SAHA 进行了平行评估,以抑制 I 类 HDACs 1、2、3 和 6。