2003 - 2006年斯里兰卡的严重登革热疫情 - Suppr

Severe dengue epidemics in Sri Lanka, 2003-2006.

作者信息

Kanakaratne Nalaka, Wahala Wahala M P B, Messer William B, Tissera Hasitha A, Shahani Aruna, Abeysinghe Nihal, de-Silva Aravinda M, Gunasekera Maya

机构信息

Genetech Research Institute, Colombo, Sri Lanka.

出版信息

Emerg Infect Dis. 2009 Feb;15(2):192-9. doi: 10.3201/eid1502.080926.

Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for >30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 1980-1997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.

登革出血热近期在印度次大陆的出现情况在斯里兰卡已有详尽记录。我们比较了斯里兰卡近期（2003 - 2006年）和过去（1980 - 1997年）的登革热监测数据。4种登革病毒（DENV）血清型在斯里兰卡共同流行已超过30年。在此期间，DENV - 1的一种新基因型取代了旧基因型。此外，DENV - 3基因型III病毒的新分支取代了旧分支。1989年和2000年DENV - 3新分支的出现与报告登革热病例数的突然增加同时发生，表明该血清型与严重疫情有关。在1980 - 1997年，大多数报告的登革热病例发生在儿童中。近期疫情的特点是儿童和成人中都有许多病例。当地传播动态的变化以及DENV - 3的基因变化可能正在增加斯里兰卡严重登革热疫情的出现频率。