Shrank William H, Cadarette Suzanne M, Cox Emily, Fischer Michael A, Mehta Jyotsna, Brookhart Alan M, Avorn Jerry, Choudhry Niteesh K
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA.
Med Care. 2009 Mar;47(3):319-25. doi: 10.1097/MLR.0b013e31818af850.
Insurers and policymakers strive to stimulate more cost-effective prescribing and, increasingly, are educating beneficiaries about generics.
To evaluate the relationship between patient beliefs and communication about generic drugs and actual drug use.
We performed a national mailed survey of a random sample of 2500 commercially-insured adults. Patient responses were linked to pharmacy claims data to assess actual generic medication use.
We used factor analysis to develop 5 multi-item scales from patient survey responses that measured: (1) general preferences for generics, (2) generic safety/effectiveness, (3) generic cost/value, (4) comfort with generic substitution, and (5) communication with providers about generics. The relationship between each scale and the proportion of prescriptions filled for generics was assessed using linear regression, controlling for demographic, health, and insurance characteristics. Separate models were created for each scale and then all 5 scales were included simultaneously in a fully-adjusted model.
The usable response rate was 48%. When evaluated independently, a 1 SD increase in each of the 5 scales was associated with a 3.1% to 6.3% increase in generic drug use (P < 0.05 for each). In the fully adjusted model, only 2 scales were significantly associated with generic drug use: comfort with generic substitution (P = 0.021) and communication with providers about generic drugs (P = 0.012).
Generic drug use is most closely associated with the 2 actionable items we evaluated: communication with providers about generics and comfort with generic substitution. Educational campaigns that focus on these 2 domains may be most effective at influencing generic drug use.
保险公司和政策制定者努力促进更具成本效益的处方开具,并且越来越多地向受益人宣传通用名药物。
评估患者对通用名药物的认知、关于通用名药物的沟通与实际用药之间的关系。
我们对2500名商业保险成年人的随机样本进行了全国性邮寄调查。将患者的回答与药房报销数据相联系,以评估实际的通用名药物使用情况。
我们使用因子分析从患者调查回答中开发了5个多项目量表,这些量表测量:(1)对通用名药物的总体偏好,(2)通用名药物的安全性/有效性,(3)通用名药物的成本/价值,(4)对通用名药物替代的接受程度,以及(5)与医疗服务提供者关于通用名药物的沟通。使用线性回归评估每个量表与通用名药物处方填充比例之间的关系,并控制人口统计学、健康状况和保险特征。为每个量表创建单独的模型,然后将所有5个量表同时纳入一个完全调整的模型。
可用回复率为48%。单独评估时,5个量表中每个量表增加1个标准差与通用名药物使用增加3.1%至6.3%相关(每个P<0.05)。在完全调整的模型中,只有2个量表与通用名药物使用显著相关:对通用名药物替代的接受程度(P = 0.021)和与医疗服务提供者关于通用名药物的沟通(P = 0.012)。
通用名药物的使用与我们评估的2个可采取行动的项目密切相关:与医疗服务提供者关于通用名药物的沟通以及对通用名药物替代的接受程度。专注于这2个领域的教育活动可能在影响通用名药物使用方面最有效。