Moseley James B, Nurse Paul
The Rockefeller University, New York, NY 10065, USA.
Curr Opin Cell Biol. 2009 Feb;21(1):82-8. doi: 10.1016/j.ceb.2008.12.005. Epub 2009 Feb 3.
Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle regulator Cdk1 and cell morphology factors such as Cdc42 coordinates the cell cycle and cell morphology in the budding and fission yeasts. During interphase, Cdk1 directly controls components of the Cdc42 regulatory module to promote polarized growth and morphological transitions. Cell morphology factors subsequently provide signals to control the Cdk1-dependent processes of mitosis and cytokinesis at the end of the cell cycle. This suggests that bidirectional signaling promotes coordinated morphology changes during the cell cycle, with general mechanisms that might operate more broadly in eukaryotic cells.
细胞在经历细胞周期时会发生显著的形态转变。在此，我们讨论普遍存在的细胞周期调节因子Cdk1与诸如Cdc42等细胞形态因子之间的通讯如何在芽殖酵母和裂殖酵母中协调细胞周期与细胞形态。在间期，Cdk1直接控制Cdc42调节模块的组成部分，以促进极化生长和形态转变。细胞形态因子随后提供信号，以在细胞周期结束时控制依赖Cdk1的有丝分裂和胞质分裂过程。这表明双向信号传导促进了细胞周期中协调的形态变化，其一般机制可能在真核细胞中更广泛地发挥作用。
