Murray M P, Turnbull K, MacQuarrie S, Pentland J L, Hill A T
Royal Infirmary of Edinburgh, Department of Respiratory Medicine, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK.
Eur Respir J. 2009 Jul;34(1):125-31. doi: 10.1183/09031936.00160508. Epub 2009 Feb 5.
Health-related quality of life is a potentially important marker for evaluating existing and new therapies in bronchiectasis. The Leicester Cough Questionnaire (LCQ) is a symptom specific questionnaire designed to assess the impact of cough severity, a major symptom of bronchiectasis. This study aimed to validate the LCQ in bronchiectasis. The validity, responsiveness and reliability of the LCQ were assessed as follows: ability to discriminate severe and mild disease; change in score following antibiotic treatment for exacerbations; repeatability over a 6-month period in stable disease; and comparison with the St George's Respiratory Questionnaire (SGRQ). In total, 120 patients (51 with severe disease, 29 with moderate disease and 40 with mild disease) completed the LCQ and SGRQ. The area under the receiver-operator curve was good for both severe and mild disease (0.84 and 0.80 respectively, p<0.0001). Following 2 weeks' antibiotic treatment, the median LCQ score (interquartile range) improved from 11.3 (9.3-13.7) to 17.8 (15-18.8) (p<0.0001). The LCQ score was repeatable over 6 months in stable disease (intraclass correlation coefficient of 0.96 (95%CI 0.93-0.97), p<0.0001). Correlation between the LCQ and SGRQ scores was -0.7 in both stable disease and exacerbations (p<0.0001). The LCQ can discriminate disease severity, is responsive to change and is reliable for use in non-cystic fibrosis bronchiectasis.
健康相关生活质量是评估支气管扩张现有和新疗法的一个潜在重要指标。莱斯特咳嗽问卷（LCQ）是一种症状特异性问卷，旨在评估咳嗽严重程度（支气管扩张的主要症状）的影响。本研究旨在验证LCQ在支气管扩张中的有效性。LCQ的有效性、反应性和可靠性评估如下：区分重度和轻度疾病的能力；急性加重期抗生素治疗后得分的变化；稳定期疾病6个月内的可重复性；以及与圣乔治呼吸问卷（SGRQ）的比较。共有120名患者（51名重度疾病患者、29名中度疾病患者和40名轻度疾病患者）完成了LCQ和SGRQ。重度和轻度疾病的受试者工作特征曲线下面积均良好（分别为0.84和0.80，p<0.0001）。经过2周的抗生素治疗，LCQ评分中位数（四分位间距）从11.3（9.3 - 13.7）提高到17.8（15 - 18.8）（p<0.0001）。在稳定期疾病中，LCQ评分在6个月内具有可重复性（组内相关系数为0.96（95%CI 0.93 - 0.97），p<0.0001）。在稳定期疾病和急性加重期，LCQ与SGRQ评分之间的相关性均为 - 0.7（p<0.0001）。LCQ能够区分疾病严重程度，对变化有反应，并且在非囊性纤维化支气管扩张中使用是可靠的。
