Vodanovich Domagoj A, Bicknell Thomas J, Holland Anne E, Hill Catherine J, Cecins Nola, Jenkins Sue, McDonald Christine F, Burge Angela T, Thompson Philip, Stirling Robert G, Lee Annemarie L
Physiotherapy, Western Health, Footscray, Vic., Australia.
Respiration. 2015;90(2):89-96. doi: 10.1159/000430992. Epub 2015 Jun 18.
The chronic respiratory disease questionnaire (CRDQ) is designed to assess health-related quality of life (HRQOL) in chronic respiratory conditions, but its reliability, validity and responsiveness in individuals with mild to moderate non-cystic fibrosis (CF) bronchiectasis are unclear.
This study aimed to determine measurement properties of the CRDQ in non-CF bronchiectasis.
Participants with non-CF bronchiectasis involved in a randomised controlled trial of exercise training were recruited. Internal consistency was assessed using Cronbach's α. Over 8 weeks, reliability was evaluated using intra-class correlation coefficients and Bland-Altman analysis for measures of agreement. Convergent and divergent validity was assessed by correlations with the other HRQOL questionnaires and the Hospital Anxiety and Depression Scale (HADS). The responsiveness to exercise training was assessed using effect sizes and standardised response means.
Eighty-five participants were included (mean age ± SD, 64 ± 13 years). Internal consistency was adequate (>0.7) for all CRDQ domains and the total score. Test-retest reliability ranged from 0.69 to 0.85 for each CRDQ domain and was 0.82 for the total score. Dyspnoea (CRDQ) was related to St George's respiratory questionnaire (SGRQ) symptoms only (r = 0.38), with no relationship to the Leicester cough questionnaire (LCQ) or HADS. Moderate correlations were found between the total score of the CRDQ, the SGRQ (rs = -0.49) and the LCQ score (rs = 0.51). Lower CRDQ scores were associated with higher anxiety and depression (rs = -0.46 to -0.56). The responsiveness of the CRDQ was small (effect size 0.1-0.24).
The CRDQ is a valid and reliable measure of HRQOL in mild to moderate non-CF bronchiectasis, but responsiveness was limited.
慢性呼吸系统疾病问卷（CRDQ）旨在评估慢性呼吸系统疾病患者与健康相关的生活质量（HRQOL），但其在轻度至中度非囊性纤维化（CF）支气管扩张症患者中的信度、效度和反应度尚不清楚。
本研究旨在确定CRDQ在非CF支气管扩张症中的测量特性。
招募参与运动训练随机对照试验的非CF支气管扩张症患者。使用Cronbach's α评估内部一致性。在8周内，使用组内相关系数和Bland-Altman分析评估一致性测量的信度。通过与其他HRQOL问卷和医院焦虑抑郁量表（HADS）的相关性评估收敛效度和区分效度。使用效应量和标准化反应均值评估对运动训练的反应度。
纳入85名参与者（平均年龄±标准差，64±13岁）。所有CRDQ领域和总分的内部一致性良好（>0.7）。每个CRDQ领域的重测信度在0.69至0.85之间，总分为0.82。呼吸困难（CRDQ）仅与圣乔治呼吸问卷（SGRQ）症状相关（r = 0.38），与莱斯特咳嗽问卷（LCQ）或HADS无关。CRDQ总分与SGRQ（rs = -0.49）和LCQ评分（rs = 0.51）之间存在中等相关性。较低的CRDQ评分与较高的焦虑和抑郁相关（rs = -0.46至-0.56）。CRDQ的反应度较小（效应量0.1 - 0.24）。
CRDQ是轻度至中度非CF支气管扩张症患者HRQOL的有效且可靠的测量工具，但反应度有限。
