Respiratory Group, Girona Biomedical Research Institute [IDIBGI], Girona, Spain.
Departament of Physical Therapy, EUSES, Girona, Spain.
Chron Respir Dis. 2021 Jan-Dec;18:14799731211036903. doi: 10.1177/14799731211036903.
Cough is a main symptom in cystic fibrosis (CF). We aim to validate a Spanish version of the Leicester Cough Questionnaire (LCQ-Sp) to measure the impact of cough in CF bronchiectasis. A prospective longitudinal multicentre study was performed. Internal consistency and score changes over a 15-day period in stable state were assessed to analyse reliability. Concurrent validity was analysed by correlation with Saint George's Respiratory Questionnaire (SGRQ) and convergent validity by assessing the association with clinical variables. Changes in scores between stable state and the first exacerbation were assessed to analyse responsiveness. 132 patients (29.73 ± 10.52 years) were enrolled in four hospitals. Internal consistency was high for the total score and good for the three domains (Cronbach's α 0.81-0.93). The test-retest reliability showed an intraclass correlation coefficient of 0.86 for the total score. The correlation between LCQ-Sp and SGRQ scores was -0.74. The LCQ-Sp score negatively correlated with sputum volume, and the mean score decreased at the beginning of exacerbations (16.04±3.81 vs 13.91±4.29) with a large effect size. The LCQ-Sp is a reliable, repeatable and responsive instrument to assess the impact of cough in CF bronchiectasis and is responsive to change in the event of exacerbations.
咳嗽是囊性纤维化（CF）的主要症状。我们旨在验证莱斯特咳嗽问卷（LCQ-Sp）的西班牙语版本，以衡量 CF 支气管扩张症咳嗽的影响。进行了一项前瞻性纵向多中心研究。评估在稳定状态下 15 天内的内部一致性和评分变化，以分析可靠性。通过与圣乔治呼吸问卷（SGRQ）的相关性分析来评估同时效度，并通过评估与临床变量的相关性来评估收敛效度。评估稳定状态与首次加重之间的评分变化，以分析反应性。在四家医院共纳入 132 名患者（29.73±10.52 岁）。总分和三个领域的内部一致性均较高（Cronbach's α 0.81-0.93）。重测信度的组内相关系数为 0.86。LCQ-Sp 与 SGRQ 评分的相关性为-0.74。LCQ-Sp 评分与痰量呈负相关，在加重开始时平均评分降低（16.04±3.81 与 13.91±4.29），具有较大的效应量。LCQ-Sp 是一种可靠、可重复和敏感的工具，可用于评估 CF 支气管扩张症咳嗽的影响，并且对加重事件有反应。
