Ross Stephen, Fallon Brian A, Petkova Eva, Feinstein Suzanne, Liebowitz Michael R
Department of Adult Psychiatry, New York University, NY, USA.
J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):450-7. doi: 10.1176/jnp.2008.20.4.450.
The authors prospectively followed patients with treatment-resistant obsessive-compulsive disorder (OCD). Between 1988 and 1995, 56 patients with a history of inadequate response to oral clomipramine received 14 infusions of intravenous clomipramine. The follow-up period ranged from 4 to 11 years after treatment. Of the 44 subjects interviewed at follow-up, 70.5% had current OCD and 29.5% had sub-threshold OCD. Almost half reported feeling much improved or very much improved compared to their state prior to treatment with intravenous clomipramine.
作者对难治性强迫症（OCD）患者进行了前瞻性随访。在1988年至1995年期间，56例对口服氯米帕明反应不佳的患者接受了14次静脉注射氯米帕明治疗。随访期为治疗后4至11年。在随访时接受访谈的44名受试者中，70.5%患有当前强迫症，29.5%患有阈下强迫症。与静脉注射氯米帕明治疗前的状态相比，近一半的人报告感觉有很大改善或非常大的改善。
