Clapauch Ruth, Braga Daniel Jorge de Castro, Marinheiro Lizanka Paola, Buksman Salo, Schrank Yolanda
Division of Female Endocrinology and Andrology, Endocrinology Sector, Hospital da Lagoa, Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ, Brazil.
Arq Bras Endocrinol Metabol. 2008 Dec;52(9):1439-47. doi: 10.1590/s0004-27302008000900006.
To analyze the relative risk of late-onset hypogonadism in men with osteoporosis and the usefulness of screening questionnaires.
We correlated the Aging Male's Symptoms (AMS), Androgen Deficiency in Aging Male (ADAM) and International Index of Erectile Function (IIEF-5) questionnaires and the laboratory diagnosis of hypogonadism in 216 men aged 50-84 years (110 with osteoporosis and 106 with normal bone density, paired by age and ethnicity).
Hypogonadism presented in 25% of the osteoporotic and in 12.2 % of normal bone density men (OR 2.08; IC95%: 1.14-3.79) and was associated with ADAM first question (low libido, p=0.013). Levels of TT below 400 ng/dl correlated with an AMS score above 26 (p=0.0278). IIEF-5 showed no correlation with testosterone levels.
Hypogonadism was 2.08 times more prevalent in osteoporotic men. The symptom that best correlated with late-onset hypogonadism was low libido (ADAM 1 positive).
分析骨质疏松男性迟发性性腺功能减退的相对风险以及筛查问卷的实用性。
我们将216名年龄在50 - 84岁的男性（110名患有骨质疏松症，106名骨密度正常，按年龄和种族配对）的衰老男性症状（AMS）、衰老男性雄激素缺乏（ADAM）和国际勃起功能指数（IIEF - 5）问卷与性腺功能减退的实验室诊断进行了关联分析。
性腺功能减退在25%的骨质疏松男性和12.2%的骨密度正常男性中出现（比值比2.08；95%置信区间：1.14 - 3.79），并且与ADAM的第一个问题（性欲减退，p = 0.013）相关。睾酮水平低于400 ng/dl与AMS评分高于26相关（p = 0.0278）。IIEF - 5与睾酮水平无相关性。
性腺功能减退在骨质疏松男性中的患病率高2.08倍。与迟发性性腺功能减退最相关的症状是性欲减退（ADAM 1阳性）。
