人类甘露糖结合凝集素多态性在肺结核中的作用。
Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis.
作者信息
Capparelli Rosanna, Iannaccone Marco, Palumbo Daniela, Medaglia Chiara, Moscariello Emilio, Russo Alfredo, Iannelli Domenico
机构信息
Faculty of Biotechnology, University of Naples Federico II, Naples, Italy.
出版信息
J Infect Dis. 2009 Mar 1;199(5):666-72. doi: 10.1086/596658.
BACKGROUND
Mannose-binding lectin (MBL) activates the complement system in an antibody-independent manner, enhances complement-mediated phagocytosis, and plays a major role in the regulation of inflammatory cytokine release by monocytes.
METHODS
Case patients (277 patients with pulmonary tuberculosis) and control subjects (288 household contacts) were tested by polymerase chain reaction (PCR) for polymorphisms at the promoter and the exon 1 regions of the MBL gene. Diagnosis of pulmonary tuberculosis, based on findings from chest radiography and sputum smear examination, was confirmed by PCR and bacteriological tests.
RESULTS
HYA/HYA subjects were protected against tuberculosis (odds ratio [OR], 0.09 [95% confidence interval {CI}], 0.023-0.408; P < 1 X 10 (-6)). LYB/LYD subjects were susceptible to disease (OR, 49 [95% CI, 2.9-812.5]; P < 1 X 10(-6)).
CONCLUSIONS
This study supports the conclusion that MBL can protect or predispose the host to tuberculosis, depending on the host's haplotype pair.
背景
甘露糖结合凝集素（MBL）以不依赖抗体的方式激活补体系统，增强补体介导的吞噬作用，并在调节单核细胞释放炎性细胞因子中起主要作用。
方法
通过聚合酶链反应（PCR）检测病例患者（277例肺结核患者）和对照受试者（288名家庭接触者）MBL基因启动子和外显子1区域的多态性。根据胸部X线检查和痰涂片检查结果诊断肺结核，并通过PCR和细菌学检测进行确诊。
结果
HYA/HYA受试者对结核病有保护作用（优势比[OR]，0.09[95%置信区间{CI}]，0.023 - 0.408；P < 1×10（-6））。LYB/LYD受试者易患该病（OR，49[95%CI，2.9 - 812.5]；P < 1×10（-6））。
结论
本研究支持以下结论，即MBL可根据宿主的单倍型对保护宿主或使宿主易患结核病。
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