Napolitano José G, Daranas Antonio H, Norte Manuel, Fernández José J
Instituto Universitario de Bioorgánica Antonio González, Universidad de La Laguna, Canary Islands, Spain.
Anticancer Agents Med Chem. 2009 Feb;9(2):122-37. doi: 10.2174/187152009787313800.
Marine organisms have attracted scientific community as a rich source of natural products with unusual structural features and remarkable biological activities. Marine macrolides are a prominent class of natural products characterized by a highly oxygenated polyene backbone containing a macrocyclic lactone as a conformational constraint. Many marine macrolides possess outstanding cell growth antiproliferative properties, making them valuable molecular probes for the investigation of biochemical pathways and promising lead compounds for the development of new antitumor chemotherapeutic agents. In the present review we intend to focus on marine macrolides with potent cytotoxic activity that could be exploited in cancer research and therapy, along with those macrolides currently in clinical trials and/or preclinical development.
海洋生物作为具有独特结构特征和显著生物活性的天然产物的丰富来源，吸引了科学界的关注。海洋大环内酯类化合物是一类重要的天然产物，其特征在于具有高度氧化的多烯主链，其中包含一个大环内酯作为构象限制。许多海洋大环内酯类化合物具有出色的细胞生长抗增殖特性，使其成为研究生化途径的有价值的分子探针，以及开发新型抗肿瘤化疗药物的有前景的先导化合物。在本综述中，我们打算重点关注具有强大细胞毒性活性、可用于癌症研究和治疗的海洋大环内酯类化合物，以及目前正在进行临床试验和/或临床前开发的那些大环内酯类化合物。
