Wang Mengchuan, Zhang Jinrong, He Shan, Yan Xiaojun
School of Marine Sciences, Laboratory of Marine Natural Products, Ningbo University, Ningbo 315211, China.
Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, China.
Mar Drugs. 2017 Apr 26;15(5):126. doi: 10.3390/md15050126.
Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of macrolides from cyanobacteria mainly manifest in the diversity of carbon skeletons, complexes of chlorinated thiazole-containing molecules and complex spatial configuration. In the present work, we systematically reviewed the structures and pharmacological activities of macrolides from cyanobacteria. Our data would help establish an effective support system for the discovery and development of cyanobacterium-derived macrolides.
蓝细菌是结构多样且具有潜在药理活性分子的丰富来源。海洋蓝细菌已被证明是一些来自海洋无脊椎动物的重要生物活性代谢产物的真正生产者。大环内酯类是一类从海洋生物中分离出的生物活性化合物，特别是包括海洋微生物。来自蓝细菌的大环内酯类的结构特征主要体现在碳骨架的多样性、含氯噻唑分子的复合物以及复杂的空间构型上。在本研究中，我们系统地综述了来自蓝细菌的大环内酯类的结构和药理活性。我们的数据将有助于建立一个有效的支持系统，以发现和开发源自蓝细菌的大环内酯类。
