Grint N J, Burford J, Dugdale A H A
Division of Veterinary Anaesthesia, University of Liverpool, Leahurst, Neston, Wirral CH64 7TE, UK.
J Small Anim Pract. 2009 Feb;50(2):73-81. doi: 10.1111/j.1748-5827.2008.00688.x.
The objective of this study was to investigate medetomidine-buprenorphine preanaesthetic medication in cats.
Forty American Society of Anesthesiologists (ASA) I female cats were enrolled in this prospective, blinded, clinical study. Cats were randomised into one of four groups: group M30 were injected intramuscularly with 30 microg/kg medetomidine, groups M10+B, M30+B and M50+B received 10, 30 and 50 microg/kg of medetomidine, respectively, each in combination with 20 microg/kg buprenorphine. After 30 minutes, a sedation score was allocated. Anaesthesia was induced using intravenous propofol and maintained using isoflurane in oxygen, while cats underwent ovariohysterectomy. Heart rate, respiratory rate, end-tidal carbon dioxide tension and oxygen saturation of haemoglobin were recorded. Atipamezole was administered intramuscularly at volatile agent discontinuation. Time taken to lift their head, sit in sternal and stand were recorded along with quality of recovery.
M30+B cats required significantly less isoflurane compared with M30 cats. Heart rate and oxygen saturation of haemoglobin were significantly lower in M50+B cats than in M30 cats. All M+B groups experienced significantly better recoveries compared with the medetomidine only M30 control group.
The addition of buprenorphine to medetomidine preanaesthetic medication in cats reduces volatile agent vaporiser setting and improves the quality of recovery from anaesthesia.
本研究的目的是调查美托咪定-丁丙诺啡在猫麻醉前用药中的效果。
40只美国麻醉医师协会（ASA）I级雌性猫被纳入这项前瞻性、双盲临床研究。猫被随机分为四组之一：M30组肌肉注射30微克/千克美托咪定，M10+B组、M30+B组和M50+B组分别接受10、30和50微克/千克美托咪定，每组均与20微克/千克丁丙诺啡联合使用。30分钟后，进行镇静评分。使用静脉注射丙泊酚诱导麻醉，并在猫进行卵巢子宫切除术时使用异氟醚和氧气维持麻醉。记录心率、呼吸频率、呼气末二氧化碳分压和血红蛋白氧饱和度。在停止使用挥发性麻醉剂时肌肉注射阿替美唑。记录猫抬头、胸骨位坐立和站立所需的时间以及恢复质量。
与M30组相比，M30+B组猫所需的异氟醚显著减少。M50+B组猫的心率和血红蛋白氧饱和度显著低于M30组。与仅使用美托咪定的M30对照组相比，所有M+B组的恢复情况均显著更好。
在猫麻醉前用药中，将丁丙诺啡添加到美托咪定中可降低挥发性麻醉剂蒸发器的设置，并提高麻醉恢复质量。
