Laing S, Paul V, Murison P J
Division of Companion Animals, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK.
J Small Anim Pract. 2009 Feb;50(2):82-6. doi: 10.1111/j.1748-5827.2008.00689.x.
To assess rate and quality of recovery from anaesthesia where isoflurane was delivered in oxygen or oxygen/nitrous oxide.
Dogs anaesthetised with propofol were randomly allocated to receive isoflurane maintenance in either 100 per cent oxygen (group 1) or 66 per cent nitrous oxide (N(2)O)/34 per cent oxygen (group 2). Time from end of anaesthesia to achieving sternal recumbency was recorded. Incidence of adverse behaviours (vocalisation, uncontrolled head movement and restlessness) were assessed. Recovery quality was recorded on a visual analogue scale (VAS) (anchored at 0 with "best possible" recovery and "did not recover" at 100 mm). Age, weight, gender, anaesthetic duration, mean vaporiser setting, VAS scores, recovery times, postoperative temperature and behavioural scores were compared (chi-squared test, Mann-Whitney U test or t-test as appropriate, significance P< or =0.05).
Objective data from 54 dogs were analysed, only VAS data where the observer was unaware of treatment group were used (n=33). Recovery was faster in group 2 dogs (median 10 min [range 4 to 31] compared with 14 minutes [3 to 43] in group 1, P=0.049) with less restlessness (0 [0 to 4] compared with 2 [0 to 4] in group 1, P=0.013) and uncontrolled head movement (0 [0 to 4] compared with 1 [0 to 3] in group 1, P<0.001). However, VAS scores were not statistically different between groups (group 1: mean 39.4 mm [s.d. 24.0)]; group 2: 30.1 mm [25.9]; P=0.303).
Addition of N(2)O to isoflurane anaesthesia results in a lower incidence of adverse behaviour (for example restlessness) and marginally faster recovery.
评估在氧气或氧气/氧化亚氮中使用异氟烷麻醉后的恢复速率和质量。
用丙泊酚麻醉的犬被随机分配，分别在纯氧（第1组）或66%氧化亚氮（N₂O）/34%氧气（第2组）中接受异氟烷维持麻醉。记录从麻醉结束到达到胸骨卧位的时间。评估不良行为（发声、头部不受控制的运动和躁动）的发生率。用视觉模拟评分法（VAS）记录恢复质量（0表示“最佳”恢复，100mm表示“未恢复”）。比较年龄、体重、性别、麻醉持续时间、平均蒸发器设置、VAS评分恢复时间、术后体温和行为评分（根据情况采用卡方检验、曼-惠特尼U检验或t检验，显著性P≤0.05）。
分析了54只犬的客观数据，仅使用观察者不知道治疗组的VAS数据（n = 33）。第2组犬的恢复更快（中位数10分钟[范围4至31]，而第1组为14分钟[3至43]，P = 0.049），躁动较少（0[范围0至4]，而第1组为2[范围0至4]，P = 0.013），头部不受控制的运动也较少（0[范围0至4]，而第1组为1[范围0至3]，P<0.001）。然而，两组之间的VAS评分无统计学差异（第1组：平均39.4mm[标准差24.0]；第2组：30.1mm[25.9]；P = 0.303）。
在异氟烷麻醉中添加N₂O可降低不良行为（如躁动）的发生率，并使恢复略快。
