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本文引用的文献

1
Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats.右美托咪定和丁丙诺啡经口腔黏膜或肌肉注射给药后对猫的镇静和镇痛作用。
Vet Anaesth Analg. 2014 Jan;41(1):90-6. doi: 10.1111/vaa.12076. Epub 2013 Aug 2.
2
Comparison of buccal and nasal dexmedetomidine premedication for pediatric patients.小儿患者口腔和鼻腔给予右美托咪定术前用药的比较。
Paediatr Anaesth. 2013 Feb;23(2):134-8. doi: 10.1111/pan.12025. Epub 2012 Sep 18.
3
Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses.右美托咪定经马舌下给药后的药代动力学和药效学
Am J Vet Res. 2011 Oct;72(10):1378-85. doi: 10.2460/ajvr.72.10.1378.
4
Bioavailability of detomidine administered sublingually to horses as an oromucosal gel.以口腔黏膜凝胶形式给马匹舌下给药时地托咪定的生物利用度。
J Vet Pharmacol Ther. 2011 Feb;34(1):76-81. doi: 10.1111/j.1365-2885.2010.01193.x.
5
Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes.通过口腔黏膜或肌肉注射途径给猫施用右美托咪定和丁丙诺啡的镇静及心肺效应。
Vet Anaesth Analg. 2010 Sep;37(5):417-24. doi: 10.1111/j.1467-2995.2010.00555.x.
6
Buccal administration of dexmedetomidine as a preanesthetic in children.口腔给予右美托咪定作为小儿麻醉前用药。
J Anesth. 2010 Feb;24(1):49-53. doi: 10.1007/s00540-009-0863-z.
7
Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration.右美托咪定给药后猫的热镇痛作用：肌肉注射与口腔粘膜下给药的比较。
J Feline Med Surg. 2009 Oct;11(10):829-34. doi: 10.1016/j.jfms.2009.03.009. Epub 2009 Jul 3.
8
Investigating medetomidine-buprenorphine as preanaesthetic medication in cats.研究美托咪定-丁丙诺啡作为猫麻醉前用药的情况。
J Small Anim Pract. 2009 Feb;50(2):73-81. doi: 10.1111/j.1748-5827.2008.00688.x.
9
Fear-related behaviour of dogs in veterinary practice.犬类在兽医诊疗过程中与恐惧相关的行为。
Vet J. 2009 Oct;182(1):38-43. doi: 10.1016/j.tvjl.2008.05.006. Epub 2008 Aug 10.
10
Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs.在犬中，右美托咪定给药前给予乙酰丙嗪或阿托品的镇静及心肺效应。
Vet Rec. 2008 Jun 28;162(26):852-6. doi: 10.1136/vr.162.26.852.

4只犬口服右美托咪定经黏膜给药用于镇静。

Oral transmucosal administration of dexmedetomidine for sedation in 4 dogs.

作者信息

Cohen Anne E, Bennett Sara L

机构信息

Animal Hospital Emergency Department (Cohen), Animal Hospital Behavior Department (Bennett), VCA Berwyn Animal Hospital, 2845 S. Harlem Ave, Berwyn, Illinois 60402, USA.

出版信息

Can Vet J. 2015 Nov;56(11):1144-8.

PMID:26538668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4608466/
Abstract

Injectable dexmedetomidine (DM) is widely used for sedation, restraint, anxiolysis, and analgesia in veterinary medicine. Oral transmucosal dexmedetomidine (OTM DM) has been evaluated in horses, cats, and humans, but not in dogs. In this case series, OTM DM (mean dose of 32.6 μg/kg body weight) was given in the buccal pouch to 4 aggressive dogs in a hospital setting. Two of the dogs were subsequently euthanized, and in the other 2, sedation was reversed with atipamezole. Satisfactory sedation was achieved in all cases.

摘要

注射用右美托咪定（DM）在兽医学中广泛用于镇静、约束、抗焦虑和镇痛。口腔黏膜用右美托咪定（OTM DM）已在马、猫和人类中进行了评估，但尚未在犬类中进行评估。在本病例系列中，在医院环境下，将OTM DM（平均剂量为32.6μg/kg体重）给予4只攻击性犬的颊囊。其中2只犬随后实施安乐死，另外2只犬用阿替美唑逆转镇静作用。所有病例均实现了满意的镇静效果。