Gervasoni Nicola, Weber Rouget Béatrice, Miguez Mélissa, Dubuis Vesselin, Bizzini Vera, Gex-Fabry Marianne, Bondolfi Guido, Aubry Jean-Michel
Service of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Switzerland.
Eur Psychiatry. 2009 Jun;24(5):341-4. doi: 10.1016/j.eurpsy.2008.12.008. Epub 2009 Feb 6.
To evaluate the performance of the French version of the Mood Disorder Questionnaire (MDQ) in patients attending a general psychiatric outpatient service as well as whether MDQ scores are independent of patient mood state at time of completion.
183 patients completed the MDQ and were assessed with the MADRS and YMRS scales, before being interviewed with the SCID (time 1). MDQ, MADRS and YMRS assessment was repeated four to six weeks later (time 2).
According to the SCID, 44 patients were suffering from bipolar spectrum disorder and 102 from unipolar disorder (37 patients dropped out). The MDQ provided high specificity (83.3%). Sensitivity was 63.6%, with better identification of bipolar I (85.0%) than bipolar II patients (45.8%). In the whole sample, test-retest reliability was satisfactory (kappa=0.64). Modest correlations were observed between the number of endorsed MDQ items and YMRS scores at time 1 (Spearman r=0.19; p=0.021) and time 2 (r=0.26; p=0.002).
Despite some fluctuations over time and a discrete influence of symptom severity, the screening algorithm can be used reliably, whether in the acute or remission phase of a depressive episode.
评估法语版心境障碍问卷（MDQ）在普通精神科门诊患者中的表现，以及MDQ评分是否独立于患者完成问卷时的情绪状态。
183名患者在接受精神障碍诊断与统计手册（SCID）访谈之前（时间1），完成了MDQ并接受了蒙哥马利-阿斯伯格抑郁量表（MADRS）和杨氏躁狂量表（YMRS）的评估。在四至六周后（时间2）重复进行MDQ、MADRS和YMRS评估。
根据SCID，44名患者患有双相谱系障碍，102名患有单相障碍（37名患者退出）。MDQ具有较高的特异性（83.3%）。敏感性为63.6%，对双相I型障碍的识别能力（85.0%）优于双相II型患者（45.8%）。在整个样本中，重测信度令人满意（kappa=0.64）。在时间1（Spearman相关系数r=0.19；p=0.021）和时间2（r=0.26；p=0.002）时，MDQ认可项目数与YMRS评分之间观察到适度的相关性。
尽管随时间存在一些波动，且症状严重程度有一定影响，但无论在抑郁发作的急性期还是缓解期，筛查算法都可可靠使用。
