Poland Gregory A, Jacobson Robert M, Ovsyannikova Inna G
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Vaccine. 2009 May 26;27(25-26):3240-4. doi: 10.1016/j.vaccine.2009.01.069. Epub 2009 Feb 5.
Important scientific, cultural, temporal, and secular issues impact the development of, and delivery of vaccines. In this paper we discuss the impact of demographics, regulatory science, the anti-vaccine movement, and finally the impact of the new biology and individualized medicine, which we call vaccinomics, on vaccine development and delivery. A description of the issues and how they have, are, or should be impacting vaccinology is provided, and hopefully will result in increased attention and discussion among vaccinologists. These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we communicate those developments, to the public.
重要的科学、文化、时代和世俗问题会影响疫苗的研发与供应。在本文中，我们将探讨人口统计学、监管科学、反疫苗运动的影响，以及最后新生物学和个性化医学（我们称之为疫苗组学）对疫苗研发与供应的影响。文中描述了这些问题以及它们已经、正在或应该如何影响疫苗学，希望能引起疫苗学家更多的关注和讨论。这些问题一直未得到充分重视、讨论不足，在某些情况下甚至被忽视。我们希望对这些问题的讨论能够改变我们研发疫苗的方式，以及我们向公众传达这些进展的方式。
