影响疫苗研发与供应未来的趋势：人口统计学、监管科学、反疫苗运动及疫苗组学的作用
Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics.
作者信息
Poland Gregory A, Jacobson Robert M, Ovsyannikova Inna G
机构信息
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Vaccine. 2009 May 26;27(25-26):3240-4. doi: 10.1016/j.vaccine.2009.01.069. Epub 2009 Feb 5.
Abstract
Important scientific, cultural, temporal, and secular issues impact the development of, and delivery of vaccines. In this paper we discuss the impact of demographics, regulatory science, the anti-vaccine movement, and finally the impact of the new biology and individualized medicine, which we call vaccinomics, on vaccine development and delivery. A description of the issues and how they have, are, or should be impacting vaccinology is provided, and hopefully will result in increased attention and discussion among vaccinologists. These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we communicate those developments, to the public.
摘要
重要的科学、文化、时代和世俗问题会影响疫苗的研发与供应。在本文中，我们将探讨人口统计学、监管科学、反疫苗运动的影响，以及最后新生物学和个性化医学（我们称之为疫苗组学）对疫苗研发与供应的影响。文中描述了这些问题以及它们已经、正在或应该如何影响疫苗学，希望能引起疫苗学家更多的关注和讨论。这些问题一直未得到充分重视、讨论不足，在某些情况下甚至被忽视。我们希望对这些问题的讨论能够改变我们研发疫苗的方式，以及我们向公众传达这些进展的方式。
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本文引用的文献
1
Immunogenetics of seasonal influenza vaccine response.季节性流感疫苗反应的免疫遗传学
Vaccine. 2008 Sep 12;26 Suppl 4(Suppl 4):D35-40. doi: 10.1016/j.vaccine.2008.07.065.
2
Personalized vaccines: the emerging field of vaccinomics.个性化疫苗：疫苗组学的新兴领域。
Expert Opin Biol Ther. 2008 Nov;8(11):1659-67. doi: 10.1517/14712598.8.11.1659.
3
Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months: a randomized trial.7个月时减少剂量方案及肌肉注射吸附炭疽疫苗对免疫原性和安全性的影响：一项随机试验
JAMA. 2008 Oct 1;300(13):1532-43. doi: 10.1001/jama.300.13.1532.
4
Vaccine immunogenetics: bedside to bench to population.疫苗免疫遗传学：从床边到实验室再到人群。
Vaccine. 2008 Nov 18;26(49):6183-8. doi: 10.1016/j.vaccine.2008.06.057. Epub 2008 Jul 1.
5
Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine.与腮腺炎病毒疫苗异质性免疫反应相关的人类白细胞抗原和细胞因子受体基因多态性
Pediatrics. 2008 May;121(5):e1091-9. doi: 10.1542/peds.2007-1575.
6
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results.Toll样受体及相关细胞内信号分子中的单核苷酸多态性与麻疹疫苗免疫反应之间的关联：初步结果
Vaccine. 2008 Mar 25;26(14):1731-6. doi: 10.1016/j.vaccine.2008.01.017. Epub 2008 Feb 4.
7
Vaccines: countering anthrax: vaccines and immunoglobulins.疫苗：对抗炭疽：疫苗与免疫球蛋白
Clin Infect Dis. 2008 Jan 1;46(1):129-36. doi: 10.1086/523578.
8
Pharmacology, vaccinomics, and the second golden age of vaccinology.药理学、疫苗组学与疫苗学的第二个黄金时代。
Clin Pharmacol Ther. 2007 Dec;82(6):623-6. doi: 10.1038/sj.clpt.6100379.
9
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Clin Pharmacol Ther. 2007 Dec;82(6):653-64. doi: 10.1038/sj.clpt.6100415. Epub 2007 Oct 31.
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