SaBio, Instituto De Investigación En Recursos Cinegéticos Irec-csic-uclm-jccm, Ciudad Real, Spain.
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.
Expert Rev Vaccines. 2021 Dec;20(12):1561-1569. doi: 10.1080/14760584.2021.1987222. Epub 2021 Oct 13.
Vaccines are a major achievement in medical sciences, but the development of more effective vaccines against infectious diseases is essential for prevention and control of emerging pathogens worldwide. The application of omics technologies has advanced vaccinology through the characterization of host-vector-pathogen molecular interactions and the identification of candidate protective antigens. However, major challenges such as host immunity, pathogen and environmental factors, vaccine efficacy and safety need to be addressed. Vaccinomics provides a platform to address these challenges and improve vaccine efficacy and safety.
In this review, we summarize current information on vaccinomics and propose quantum vaccinomics approaches to further advance vaccine development through the identification and combination of antigen protective epitopes, the immunological quantum. The COVID-19 pandemic caused by SARS-CoV-2 is an example of emerging infectious diseases with global impact on human health.
Vaccines are required for the effective and environmentally sustainable intervention for the control of emerging infectious diseases worldwide. Recent advances in vaccinomics provide a platform to address challenges in improving vaccine efficacy and implementation. As proposed here, quantum vaccinomics will contribute to vaccine development, efficacy, and safety by facilitating antigen combinations to target pathogen infection and transmission in emerging infectious diseases.
疫苗是医学科学的重大成就，但开发更有效的传染病疫苗对于预防和控制全球新出现的病原体至关重要。组学技术的应用通过宿主-载体-病原体分子相互作用的特征描述和候选保护性抗原的鉴定，推动了疫苗学的发展。然而，需要解决主要挑战，如宿主免疫、病原体和环境因素、疫苗效力和安全性。疫苗组学提供了一个平台来应对这些挑战，提高疫苗的效力和安全性。
在这篇综述中，我们总结了疫苗组学的最新信息，并提出了量子疫苗组学方法，通过识别和组合抗原保护性表位（免疫量子）来进一步推进疫苗开发。由 SARS-CoV-2 引起的 COVID-19 大流行是对人类健康具有全球影响的新发传染病的一个例子。
疫苗是全球有效和环境可持续干预新发传染病的必要手段。最近在疫苗组学方面的进展为提高疫苗效力和实施方面的挑战提供了一个平台。正如这里所提出的，量子疫苗组学将通过促进针对新发传染病中病原体感染和传播的抗原组合，为疫苗开发、效力和安全性做出贡献。
