Panatto D, Amicizia D, Ansaldi F, Marocco A, Marchetti F, Bamfi F, Giacchino R, Tacchella A, Del Buono S, Gasparini R
Department of Health Science, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.
Vaccine. 2009 May 26;27(25-26):3450-3. doi: 10.1016/j.vaccine.2009.01.054. Epub 2009 Feb 5.
Rotavirus is acknowledged to be a major cause of acute gastroenteritis in infants and young children. As gastroenteritis due to rotavirus is a public health problem and two new vaccines are currently available, we investigated the rotavirus burden and developed a cost-effectiveness analysis, using data collected in the Province of Genoa (Italy), to evaluate the benefits of new borns vaccination. The cost-effectiveness of a rotavirus vaccination programme in the Province of Genoa was performed, in comparison with no vaccination, for both the regional healthcare system (RHS) and society (S). In 2006, admissions to the paediatric emergency department for gastroenteritis numbered 2338 (about 11% of total admissions); of these 33% were hospitalised. In 28% of cases, the children tested positive for rotavirus. During epidemics, paediatricians receive from 3 to 5 calls per day for gastroenteritis, carry out 1 or 2 ambulatory examinations and for children with a severe case history, make house visits. A rotavirus immunisation programme would have a great impact on disease burden, in that 90% coverage would reduce the number of severe cases by more than 85%. From the perspective of both the RHS and S, vaccination proved to be highly cost-effective.
轮状病毒被认为是婴幼儿急性胃肠炎的主要病因。由于轮状病毒引起的胃肠炎是一个公共卫生问题，且目前有两种新型疫苗可供使用，我们利用在意大利热那亚省收集的数据，调查了轮状病毒负担并开展了成本效益分析，以评估新生儿接种疫苗的益处。针对热那亚省轮状病毒疫苗接种计划，与未接种疫苗的情况相比，分别从地区医疗系统（RHS）和社会（S）的角度进行了成本效益分析。2006年，因胃肠炎入住儿科急诊科的人数为2338人（约占总入院人数的11%）；其中33%的患者住院治疗。在28%的病例中，儿童轮状病毒检测呈阳性。在疫情期间，儿科医生每天接到3至5个关于胃肠炎的电话，进行1至2次门诊检查，并对病史严重的儿童进行家访。轮状病毒免疫计划将对疾病负担产生重大影响，即90%的覆盖率将使重症病例数减少85%以上。从地区医疗系统和社会的角度来看，接种疫苗都被证明具有很高的成本效益。
