Maremmani Icro, Pacini Matteo, Popovic Dina, Romano Anna, Maremmani Angelo G I, Perugi Giulio, Deltito Joseph, Akiskal Kareen, Akiskal Hagop
Vincent P. Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, 56100 Pisa Italy.
J Affect Disord. 2009 Oct;117(3):186-92. doi: 10.1016/j.jad.2009.01.007. Epub 2009 Feb 6.
Much of the literature has described personality disorder constructs for heroin addicts. Building on previous work we examine the relevance of affective temperament measures in these patients.
59 consecutive stabilized methadone treated heroin addicts, 34 with and 25 without psychiatric comorbidity, were compared, regarding affective temperaments, according to the Akiskal and Mallya formulation, with 58 healthy volunteers sharing similar social and regional demographics.
No differences were observed between heroin addicts and controls on either depressive or hyperthymic scales. Significant discrepancies were noted in cyclothymic and irritability scales, on which heroin addicts scored higher, regardless of the presence or absence of a dual diagnosis. In a multivariate discriminant analysis, mainly cyclothymic, and (to a lesser extent) irritable traits show a distinction between heroin addicts and controls, but not between heroin addicts with and without dual diagnoses.
Cross-sectional study.
Our data suggest a new hypothesis. Cyclothymic, and to a lesser extent irritable traits (the "dark side"), could represent the temperamental profile of heroin addicts, largely irrespective of comorbidity, and tend to cohere with previous conceptualizations hypothesizing "sensation-seeking" (and "novelty-seeking") as the main personality characteristics of addiction.
许多文献都描述了海洛因成瘾者的人格障碍结构。基于先前的研究工作,我们研究了这些患者中情感气质测量的相关性。
根据阿基斯卡尔和马利亚的公式,将59名连续接受美沙酮治疗且病情稳定的海洛因成瘾者(34名有精神疾病共病,25名无精神疾病共病)与58名具有相似社会和地区人口统计学特征的健康志愿者在情感气质方面进行比较。
在抑郁或轻躁狂量表上,海洛因成瘾者与对照组之间未观察到差异。在环性心境障碍和易怒量表上发现了显著差异,无论是否存在双重诊断,海洛因成瘾者在这些量表上的得分都更高。在多变量判别分析中,主要是环性心境障碍以及(程度较轻的)易怒特质显示出海洛因成瘾者与对照组之间的区别,但在有双重诊断和无双重诊断的海洛因成瘾者之间没有区别。
横断面研究。
我们的数据提出了一个新的假设。环性心境障碍以及程度较轻的易怒特质(“阴暗面”)可能代表了海洛因成瘾者的气质特征,很大程度上与共病无关,并且倾向于与先前将“寻求刺激”(和“寻求新奇”)假设为成瘾主要人格特征的概念化观点相一致。