Wagener Gebhard, Gubitosa Gina, Wang Shuang, Borregaard Niels, Kim Mihwa, Lee H Thomas
Department of Anesthesiology, College of Physicians and Surgeons, New York, NY, USA.
J Cardiothorac Vasc Anesth. 2009 Apr;23(2):195-9. doi: 10.1053/j.jvca.2008.11.018. Epub 2009 Feb 7.
The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery.
A matched cohort study.
A tertiary university hospital.
Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump) matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine, Parsonnet score, ejection fraction, body mass index, and number of coronary artery grafts.
None, observational.
Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before and immediately after surgery and then 3, 18, and 24 hours later. There were no differences in urinary NGAL at any time point between patients subjected to off-pump or on-pump CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery was 94.7 +/- 30.9 ng/mL compared with 122.7 +/- 57.0 ng/mL in patients with on-pump CABG surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were not different between the groups.
Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery despite a very good match between the groups with respect to pre- and intraoperative risk factors.
本研究旨在比较非体外循环和体外循环冠状动脉旁路移植术（CABG）中尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平。
一项匹配队列研究。
一所三级大学医院。
30例接受非体外循环（非体外循环）CABG手术的成年患者，根据年龄、术前血清肌酐、Parsonnet评分、射血分数、体重指数和冠状动脉移植数量，与30例体外循环CABG手术患者相匹配。
无，观察性研究。
测量术前、术后即刻以及术后3、18和24小时尿NGAL水平，尿NGAL是一种用于肾损伤的新型高敏生物标志物。非体外循环或体外循环CABG手术患者在任何时间点的尿NGAL水平均无差异；非体外循环CABG手术患者尿NGAL峰值为94.7 +/- 30.9 ng/mL，而体外循环CABG手术患者为122.7 +/- 57.0 ng/mL（p = 0.6）。两组间血清肌酐峰值和急性肾损伤发生率也无差异。
尽管两组在术前和术中危险因素方面匹配良好，但非体外循环和体外循环CABG手术患者的尿NGAL水平并无差异。
