Jardri Renaud, Pins Delphine, Bubrovszky Maxime, Lucas Bernard, Lethuc Vianney, Delmaire Christine, Vantyghem Vincent, Despretz Pascal, Thomas Pierre
Laboratoire de Neurosciences Fonctionnelles et Pathologies, CNRS UMR-8160, Hôpital Roger Salengro, Université Lille Nord de France, Centre Hospitalier Universitaire de Lille, 59037 Lille cedex, France.
Conscious Cogn. 2009 Jun;18(2):449-57. doi: 10.1016/j.concog.2008.12.009. Epub 2009 Feb 6.
Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.
尽管复杂幻觉在精神分裂症中极为生动且令人痛苦，但对于这种现象中多感官整合的潜在机制却知之甚少。我们通过结合功能磁共振成像、扩散张量成像、皮层厚度分析、电源重建和经颅磁刺激等先进的神经科学探索方法，研究了一名精神分裂症患者这些意识改变状态的神经基础。研究结果揭示了幻觉过程的功能结构，其中来自不同模态的单峰信息与高阶整合区域在功能上紧密相连。
