Nanda Saheba, Priya Krishna, Khan Tasmia, Patel Puja, Azizi Heela, Nuthalapati Deepa, Paul Christen, Sippy Rabina, Simsam Abdulkader Hmidan, Abraham Jesslin, Singh Gurjinder, Goodarzi Alireza, Ojimba Chiedozie, Jolayemi Ayodeji
American University of Antigua College of Medicine, Department of Psychiatry, Interfaith Medical Center, Brooklyn, New York, USA.
Department of Psychiatry, Interfaith Medical Center, Brooklyn, New York, USA.
Psychiatry J. 2020 Jan 22;2020:4262050. doi: 10.1155/2020/4262050. eCollection 2020.
Brain imaging studies have identified multiple neuronal networks and circuits in the brain with altered functioning in patients with schizophrenia. These include the hippocampo-cerebello-cortical circuit, the prefrontal-thalamic-cerebellar circuit, functional integration in the bilateral caudate nucleus, and the salience network consisting of the insular cortex, parietal anterior cingulate cortex, and striatum, as well as limbic structures. Attributing psychotic symptoms to any of these networks in schizophrenia is confounded by the disruption of these networks in schizophrenic patients. Such attribution can be done with isolated dysfunction in any of these networks with concurrent psychotic symptoms. We present the case of a patient who presents with new-onset hallucinations and a stroke in brain regions similar to the salience network (insular cortex, parietal cortex, and striatum). The implication of these findings in isolating psychotic symptoms of the salience network is discussed.
脑成像研究已确定大脑中多个神经元网络和回路，精神分裂症患者的这些网络功能发生了改变。这些包括海马 - 小脑 - 皮质回路、前额叶 - 丘脑 - 小脑回路、双侧尾状核的功能整合，以及由岛叶皮质、顶叶前扣带回皮质和纹状体以及边缘结构组成的显著性网络。将精神分裂症的精神病症状归因于这些网络中的任何一个，都因精神分裂症患者这些网络的破坏而变得复杂。这种归因可以在这些网络中任何一个出现孤立功能障碍并伴有并发精神病症状的情况下进行。我们报告了一例患者，该患者出现新发幻觉，且在与显著性网络（岛叶皮质、顶叶皮质和纹状体）相似的脑区发生了中风。本文讨论了这些发现对分离显著性网络的精神病症状的意义。
