猫子宫内膜腺癌的免疫组织化学研究

An immunohistochemical study of feline endometrial adenocarcinoma.

作者信息

Gil da Costa R M, Santos M, Amorim I, Lopes C, Pereira P Dias, Faustino A M

机构信息

Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Pathology and Molecular Immunology, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal.

出版信息

J Comp Pathol. 2009 May;140(4):254-9. doi: 10.1016/j.jcpa.2008.12.006. Epub 2009 Feb 7.

DOI:10.1016/j.jcpa.2008.12.006

PMID:19201419

Abstract

Feline endometrial adenocarcinomas are uncommon malignant neoplasms that have to date been poorly characterized. The present immunohistochemical study describes the expression of the pancytokeratins AE1 and AE3, cytokeratin-14, vimentin, alpha-actin, cyclo-oxygenase-2, E-cadherin, beta-catenin, the progesterone receptor, the oestrogen receptor and caveolin-1 within normal feline uterine tissue and tissue from six cats with endometrial adenocarcinoma. Synthesis of cyclo-oxygenase-2 and reduced expression of progesterone receptors may be involved in the neoplastic transformation of feline endometrium. The loss of cellular adhesion that occurs within these tumours does not require down-regulation of E-cadherin expression and nuclear translocation of beta-catenin is not a feature of these neoplasms.

摘要

猫子宫内膜腺癌是一种罕见的恶性肿瘤，迄今为止其特征尚未明确。本免疫组织化学研究描述了全细胞角蛋白AE1和AE3、细胞角蛋白-14、波形蛋白、α-肌动蛋白、环氧化酶-2、E-钙黏蛋白、β-连环蛋白、孕激素受体、雌激素受体和小窝蛋白-1在正常猫子宫组织和六只患有子宫内膜腺癌的猫的组织中的表达情况。环氧化酶-2的合成和孕激素受体表达的降低可能参与了猫子宫内膜的肿瘤转化。这些肿瘤中发生的细胞黏附丧失并不需要E-钙黏蛋白表达下调，β-连环蛋白的核转位也不是这些肿瘤的特征。