Hohaus Stefan, Giachelia Manuela, Massini Giuseppina, Vannata Barbara, Criscuolo Marianna, Martini Maurizio, D'Alo' Francesco, Voso Maria Teresa, Larocca Luigi Maria, Leone Giuseppe
Istituto di Ematologia, Universita' Cattolica S. Cuore, Rome, Italy.
Leuk Res. 2009 Oct;33(10):1352-6. doi: 10.1016/j.leukres.2009.01.009. Epub 2009 Feb 8.
We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
我们研究了霍奇金淋巴瘤（HL）患者的白细胞介素-10（IL-10）血浆水平以及白细胞介素-10（IL-10）基因启动子中的五个单核苷酸多态性，以探讨潜在的基因型-表型相关性。IL-10水平升高的患者更有可能患有晚期疾病且无事件生存期较差。IL-10启动子-592位（AA）和-1082位（GG）变异等位基因的纯合携带者具有较高的IL-10血浆水平，这与男性性别和疾病晚期无关，而男性性别和疾病晚期也会导致IL-10产生增加。该分析表明，遗传背景可调节HL患者的IL-10血浆水平，并最终影响其预后。
