Helminen M E, Kilpinen S, Virta M, Hurme M
Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
J Infect Dis. 2001 Sep 15;184(6):777-80. doi: 10.1086/322987. Epub 2001 Aug 7.
In total, 116 children were investigated to determine whether the interleukin (IL)-10 polymorphism influences the age at primary Epstein-Barr virus (EBV) infection. The promoter of IL-10 is polymorphic, with 3 known single base substitutions (G/A at -1082, C/T at -819, and C/A at -592), which form 3 haplotypes: GCC, ACC, and ATA. This study found that carriage of the ATA haplotype protects against early EBV infection. The presence of the ATA haplotype was associated with EBV seronegativity (odds ratio, 2.6; 95% confidence interval, 1.04-6.7; P=.04), when controlled by age. To examine the effect of haplotypes on IL-10 production, IL-10 plasma levels were measured in 50 newborns and 400 adults and were correlated with the IL-10 haplotype. The IL-10 levels were significantly higher in the ATA carriers than in the noncarriers. These data suggest that the IL-10 ATA haplotype confers protection against primary EBV infection and that the effect is mediated by high IL-10 levels.
共有116名儿童接受了调查，以确定白细胞介素（IL）-10基因多态性是否会影响原发性爱泼斯坦-巴尔病毒（EBV）感染的年龄。IL-10的启动子具有多态性，有3种已知的单碱基替换（-1082位的G/A、-819位的C/T和-592位的C/A），形成3种单倍型：GCC、ACC和ATA。本研究发现，ATA单倍型的携带可预防早期EBV感染。在按年龄进行校正后，ATA单倍型的存在与EBV血清阴性相关（优势比，2.6；95%置信区间，1.04 - 6.7；P = 0.04）。为了研究单倍型对IL-10产生的影响，对50名新生儿和400名成年人的血浆IL-10水平进行了测量，并将其与IL-10单倍型进行关联分析。ATA携带者的IL-10水平显著高于非携带者。这些数据表明，IL-10 ATA单倍型可预防原发性EBV感染，且这种作用是由高水平的IL-10介导的。
