抗破伤风和白喉类毒素IgG抗体的血清滴度与多发性硬化症风险
Serum titers of IgG antibodies against tetanus and diphtheria toxoids and risk of multiple sclerosis.
作者信息
Massa J, Munger K L, O'Reilly E J, Levin L I, Ascherio A
机构信息
Department of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USA.
出版信息
J Neuroimmunol. 2009 Mar 31;208(1-2):141-2. doi: 10.1016/j.jneuroim.2009.01.006. Epub 2009 Feb 7.
We conducted a prospective nested case-control study among military service members to investigate whether antibodies against tetanus or diphtheria predict multiple sclerosis (MS) risk. Paired T-tests were used to compare means of anti-tetanus and diphtheria toxoids among 56 MS cases and 112 matched controls. Conditional logistic regression was used to estimate odds ratios (OR). There were no differences between the mean serum IgG antibodies against tetanus (p-value 0.28) or diphtheria (p-value 0.45) in the baseline samples. The OR of MS associated with 1 standard deviation difference in antibody titers was 0.76 (95% CI: 0.48-1.21) for tetanus (SD=4.71) and 1.03 (0.73-1.45) for diphtheria (SD=0.87). Results of this study suggest serum IgG antibodies against tetanus or diphtheria are not predictors of MS risk.
我们在军人中开展了一项前瞻性巢式病例对照研究，以调查破伤风或白喉抗体是否可预测多发性硬化症（MS）风险。采用配对t检验比较56例MS病例和112例匹配对照中抗破伤风和白喉类毒素的均值。使用条件逻辑回归估计比值比（OR）。基线样本中抗破伤风（p值0.28）或抗白喉（p值0.45）的血清IgG抗体均值无差异。破伤风抗体滴度相差1个标准差时MS的OR为0.76（95%CI：0.48-1.21）（标准差=4.71），白喉抗体滴度相差1个标准差时MS的OR为1.03（0.73-1.45）（标准差=0.87）。本研究结果表明，抗破伤风或抗白喉血清IgG抗体并非MS风险的预测指标。
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