Lamoureux G, Giard N, Jolicoeur R, Toughlian V, Desrosiers M
Br Med J. 1976 Jan 24;1(6003):183-6. doi: 10.1136/bmj.1.6003.183.
A clinical and laboratory profile of the immunological system of patients with multiple sclerosis (MS) strongly suggested that many specific immune deficiencies exist in MS. The immunological history showed that patients with MS had had more tonsillectomies, appendicectomies, and childhood infections than matched controls, which suggested that there had been problems in controlling various types of childhood infections. The cell-mediated immune response and the circulating antibody titres were specifically impaired against a variety of antigens. Patients with MS had significantly lower serum antibody titres than controls against many naturally occurring antigens-namely, diptheria and tetanus toxoids, adenovirus, and mumps viruses. Raised serum antibody titres were found against measles and varicella zoster viruses while no difference was found towards other antigens. The delayed hypersensitivity reaction and the immunological memory of patients with MS were also greatly reduced against the mumps skin test antigens. There were normal amounts of circulating T and B lymphocytes, and the phytohaemagglutinin, concanavallin A, pokeweed mitogen, and encephalitogens lymphocyte transformation was not different from that in controls. These results indicated that patients with MS have more infectious problems than normal people and that both their T and B cell systems cannot mount a fully normal immunological response to some viral and bacterial antigens, while they give an increased response to others.
多发性硬化症（MS）患者免疫系统的临床和实验室特征强烈表明，MS存在许多特定的免疫缺陷。免疫病史显示，与匹配的对照组相比，MS患者进行扁桃体切除术、阑尾切除术和儿童期感染的情况更多，这表明在控制各种类型的儿童期感染方面存在问题。细胞介导的免疫反应和循环抗体滴度针对多种抗原受到特异性损害。与许多天然存在的抗原（即白喉和破伤风类毒素、腺病毒和腮腺炎病毒）相比，MS患者的血清抗体滴度显著低于对照组。发现针对麻疹和水痘带状疱疹病毒的血清抗体滴度升高，而对其他抗原未发现差异。MS患者对腮腺炎皮肤试验抗原的迟发型超敏反应和免疫记忆也大大降低。循环T淋巴细胞和B淋巴细胞数量正常，植物血凝素、刀豆球蛋白A、商陆有丝分裂原和致脑炎原的淋巴细胞转化率与对照组无差异。这些结果表明，MS患者比正常人有更多的感染问题，他们的T细胞和B细胞系统对某些病毒和细菌抗原都不能产生完全正常的免疫反应，而对其他抗原则反应增强。
