Dibbets Pauline, Evers Lisbeth, Hurks Petra, Marchetta Natalie, Jolles Jelle
Maastricht University, Universiteitssingel 50, Clinical Psychological Science, P.O. Box 616, 6200MD, Maastricht, The Netherlands.
Brain Cogn. 2009 Jun;70(1):73-83. doi: 10.1016/j.bandc.2009.01.001. Epub 2009 Feb 7.
The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-related differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD.
本研究的目的是使用事件相关功能磁共振成像来检测患有注意力缺陷多动障碍（ADHD）的成年人中与反应抑制及反馈相关的神经活动。16名患有ADHD的成年男性和13名健康/正常对照者参与了本研究，并执行了一项改良的Go/NoGo任务。行为学上，观察到ADHD组存在注意力和抑制问题；未检测到两组之间与反馈相关的差异。神经影像学数据显示，ADHD组在反应抑制期间，额下回和壳核的激活更多。在与反馈相关的过程中，ADHD组在额下/眶额皮质、海马/伏隔核和尾状核的激活较少，但在额下回的活动较多。这些结果表明，至少有两个与反应抑制和反馈相关的可区分的潜在脑网络在患有ADHD的成年人中发生了改变。
