高碳酸血症诱发的反复呼吸急促体验：对强度和不适感的不同影响。
Repeated breathlessness experiences induced by hypercapnia: differential effects on intensity and unpleasantness.
作者信息
Wan Li, Van Diest Ilse, De Peuter Steven, Bogaerts Katleen, Van den Bergh Omer
机构信息
Department of Psychology, University of Leuven, Leuven, Belgium.
Department of Psychology, University of Leuven, Leuven, Belgium.
出版信息
Chest. 2009 Feb;135(2):455-461. doi: 10.1378/chest.08-1226.
BACKGROUND
The present study investigated the effect of repeated hypercapnic challenges on the sensory (intensity [I]) and affective (unpleasantness [U]) dimensions of breathlessness.
METHODS
Three subsequent rebreathing trials (Read, 1968) were administered to healthy men and women (n = 39). The I and U of breathlessness were rated every 20 s during the baseline, rebreathing, and recovery phases. Breathing behavior (fractional end-tidal CO(2) [Fetco(2)] and minute ventilation [Ve]) was monitored continuously. Intraindividual linear regression slopes for Fetco(2) and Ve] were calculated and standardized, separately for both rating dimensions.
RESULTS
Both the absolute magnitude and the slope of the I of breathlessness were higher compared to U (p < 0.05). Across-trial habituation of the peak I and U of breathlessness occurred in both genders (p < 0.001), but habituation was larger for the U than for the I (p = 0.05).
CONCLUSIONS
The findings show that the sensory and affective dimensions of breathlessness can meaningfully be distinguished during hypercapnic challenges and that repeated exposures have different effects on both dimensions.
背景
本研究调查了反复高碳酸血症激发试验对呼吸困难的感觉维度（强度[I]）和情感维度（不愉快程度[U]）的影响。
方法
对39名健康男性和女性进行了三次连续的重复呼吸试验（Read，1968）。在基线期、重复呼吸期和恢复期，每隔20秒对呼吸困难的I和U进行评分。持续监测呼吸行为（潮气末二氧化碳分数[Fetco₂]和分钟通气量[Ve]）。分别针对两个评分维度计算并标准化Fetco₂和Ve的个体内线性回归斜率。
结果
与U相比，呼吸困难I的绝对值和斜率均更高（p < 0.05）。男性和女性的呼吸困难的峰值I和U在试验过程中均出现了适应性变化（p < 0.001），但U的适应性变化大于I（p = 0.05）。
结论
研究结果表明，在高碳酸血症激发试验期间，可以有效区分呼吸困难的感觉维度和情感维度，并且反复暴露对这两个维度有不同的影响。
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