口服植物乳杆菌NRIC0380可在体内抑制IgE产生并诱导CD4(+)CD25(+)Foxp3(+)细胞。
Oral administration of Lactobacillus plantarum NRIC0380 suppresses IgE production and induces CD4(+)CD25(+)Foxp3(+) cells in vivo.
作者信息
Enomoto Mai, Noguchi Sayo, Hattori Makoto, Sugiyama Hisashi, Suzuki Yasuyuki, Hanaoka Akihiro, Okada Sanae, Yoshida Tadashi
机构信息
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Feb;73(2):457-60. doi: 10.1271/bbb.80438. Epub 2009 Feb 7.
The influence of lactic acid bacteria (LAB) on CD4(+)Foxp3(+) cells has not been investigated, although it has been reported that CD4(+)Foxp3(+) cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4(+)Foxp3(+) generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4(+)CD25(+)Foxp3(+) cells in whole CD4(+) cells was significantly higher in both Peyer's patch and the spleen of mice that had been fed with LAB than in the control mice.
尽管有报道称CD4(+)Foxp3(+)细胞可能参与抑制过敏症状，但乳酸菌（LAB）对CD4(+)Foxp3(+)细胞的影响尚未得到研究。因此，我们研究了口服LAB对CD4(+)Foxp3(+)细胞生成的影响。与先前研究报道的其他一些菌株一样，口服植物乳杆菌NRIC0380可显著抑制抗原特异性IgE的产生并增强Th1反应。在喂食LAB的小鼠的派尔集合淋巴结和脾脏中，全CD4(+)细胞中CD4(+)CD25(+)Foxp3(+)细胞的比例显著高于对照小鼠。
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