蝙蝠葛培养根的无细胞制剂将去氯蝙蝠葛碱转化为米哈明碱。

Conversion of dechlorodauricumine into miharumine by a cell-free preparation from cultured roots of Menispermum dauricum.

作者信息

Hori Rieko, Sugimoto Gen, Matsui Miharu, Yamauchi Yasuo, Takikawa Hirosato, Sugimoto Yukihiro

机构信息

Graduate School of Agricultural Science, Kobe University, Rokkodai, Nada, Japan.

出版信息

Biosci Biotechnol Biochem. 2009 Feb;73(2):440-2. doi: 10.1271/bbb.80596. Epub 2009 Feb 7.

DOI:10.1271/bbb.80596

PMID:19202273

Abstract

Dechlorodauricumine (5) and dechloroacutumine (6) were converted to miharumine (7) and dechloroacutumidine (8), respectively, by a cell-free preparation from cultured roots of Menispermum dauricum in the presence of FAD. The structures of 7 and 8 were elucidated on the basis of spectroscopic analyses and chemical conversion.

摘要

在黄素腺嘌呤二核苷酸（FAD）存在的情况下，蝙蝠葛碱（5）和去氯尖防己碱（6）分别被蝙蝠葛培养根的无细胞制剂转化为米哈明碱（7）和去氯尖防己定（8）。基于光谱分析和化学转化确定了7和8的结构。