酿酒酵母中核糖体生物合成与肌醇多磷酸代谢之间的遗传相互作用。
Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiae.
作者信息
Horigome Chihiro, Ikeda Ryo, Okada Takafumi, Takenami Kazuhiko, Mizuta Keiko
机构信息
Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Feb;73(2):443-6. doi: 10.1271/bbb.80599. Epub 2009 Feb 7.
Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.
Rrs1在酿酒酵母60S核糖体亚基组装中起关键作用。我们分离出了一个温度敏感型kcs1突变体，它能抑制rrs1-1的冷敏感性。导致肌醇6磷酸激酶结构域截短的kcs1等位基因以及kcs1基因敲除可抑制rrs1-1在60S核糖体亚基组装中的缺陷。这些结果表明肌醇多磷酸代谢影响酵母中的核糖体生物合成。
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